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首页 >> 咖啡專欄 >>咖友生活八卦 >> 咖啡與癌症內在關系的統計結果

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咖啡與癌症內在關系的統計結果

咖啡是用經過烘焙的咖啡豆制作出來的飲料，與可可、茶同爲流行于世界的主要飲品。

咖啡中含有咖啡豆醇和咖啡醇，具有抗癌和抗炎的作用。咖啡能上調肝髒中的抗毒生化過程，保護身體免受黃曲黴毒素和其它致癌物質的影響。

同時，一些觀察性研究表明，咖啡攝入量可能與胃癌風險增加有關，但目前各研究結果不一致。因此研究者進行了一項荟萃分析，評估胃癌風險和咖啡攝入量的關系，並量化兩者間的劑量-反應關系。

研究者檢索了PubMed、EMBASE等數據庫中相關的前瞻性研究，使用隨機效應模型計算彙總後風險估計和95%置信區間；使用I（2）統計值估計異質性；使用Begg檢驗和Egger檢驗評估發表偏倚。

该荟萃分析最终纳入了13个前瞻性研究共20项独立报告，涉及3368例胃癌患者和1372811名参与者，随访时间4.3-8年。与咖啡摄入量最低的组相比，胃癌风险RR=1.13（95 % CI: 0.94-1.35）。剂量-反应分析表明，每人每天喝3杯咖啡，胃癌风险RR=1.03 (95 % CI; 0.95-1.11)。研究者没有发现咖啡摄入量与胃癌风险间的任何非线性关联（非线性，P= 0.68）。亚组分析表明，美国地区咖啡摄入量最高和最低组相比，胃癌风险RR=1.36 (95 % CI, 1.06-1.75, I (2) = 0 %)。此外，不到10年的随访数据显示，随着咖啡摄入量的增加，胃癌风险增加25%(RR = 1.25; 95 % CI, 1.01-1.55, I (2) = 0 %)。漏斗图、Begg's和Egger's检验没有发现发表偏倚。

該荟萃結果不支持咖啡攝入量與胃癌風險的關系，但是根據美國的不到10年的隨訪組數據，研究人員發現隨咖啡攝入量增加胃癌風險增加。未來還需要更多的相關研究探究兩者間的關系。

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"We walked by the side of our teams or behind the wagons, we slept on the ground at night, we did our own cooking, we washed our knives by sticking them into the ground rapidly a few times, and we washed our plates with sand and wisps of grass. When we stopped, we arranged our wagons in a circle, and thus formed a 'corral,' or yard, where we drove our oxen to yoke them up. And the corral was often very useful as a fort, or camp, for defending ourselves against the Indians. Do you see that little hollow down there?" he asked, pointing to a depression in the ground a short distance to the right of the train. "Well, in that hollow our wagon-train was kept three days and nights by the Indians. Three days and nights they stayed around, and made several attacks. Two of our men were killed and three were wounded by their arrows, and others had narrow escapes. One arrow hit me on the throat, but I was saved by the knot of my neckerchief, and the point only tore the skin a little. Since that time I have always had a fondness for large neckties. I don't know how many of the Indians we killed, as they carried off their dead and wounded, to save them from being scalped. Next to getting the scalps of their enemies, the most important thing with the Indians is to save their own. We had several fights during our journey, but that one was the worst. Once a little party of us were surrounded in a small 'wallow,' and had a tough time to defend ourselves successfully. Luckily for us, the Indians had no fire-arms then, and their bows and arrows were no match for our rifles. Nowadays they are well armed, but there are[Pg 41] not so many of them, and they are not inclined to trouble the railway trains. They used to do a great deal of mischief in the old times, and many a poor fellow has been killed by them." The boys looked in the direction indicated, but could see nothing. This is not surprising, when we remember that sailors' eyes are accustomed to great distances, and can frequently see objects distinctly long before landsmen can make them out. Mr. Charlton's melancholy eyes seemed to be fixed on space. Just for the moment he had forgotten that he was not alone. Lawrence gave a sympathetic cough. As a matter of fact, he had not yet explained what he was doing there, and the longer the explanation was postponed the better he would be pleased. "You see our patient has gone," Balmayne said smoothly. "As a matter of fact, the whole thing was a ridiculous mistake. But you must not blame us. The blame is due to the charming young lady who sent for you. But that is one of the drawbacks of your noble profession. Goodnight." In one of the inmost circles, a sacred elephant had gone must, breaking his ropes, and confined now by only one leg. 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